Model-Assisted Bayesian Designs for Dose Finding and Optimization (Chapman & Hall/CRC Biostatistics Series) 1st Edition

400 850 

Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials.

The objective of this book is to describe the state-of-the-art model-assisted designs to facilitate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs, yet their decision rules often can be pre-tabulated and included in the protocol―making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design, the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency’s support of the use of the novel adaptive design to improve drug development.

Features

  • Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials
  • Describes the up-to-date theory and practice for model-assisted designs
  • Presents many practical challenges, issues, and solutions arising from early-phase clinical trials
  • Illustrates with many real trial applications
  • Offers numerous tips and guidance on designing dose finding and optimization trials
  • Provides step-by-step illustrations of using software to design trials
  • Develops a companion website (www.trialdesign.org) to provide freely available, easy-to-use software to assist learning and implementing model-assisted designs

Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center, this book shows how model-assisted designs can greatly improve the efficiency and simplify the design, conduct, and optimization of early-phase dose-finding trials. It should therefore be a very useful practical reference for biostatisticians, clinicians working in clinical trials, and drug regulatory professionals, as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart!

 

 

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Description

Model-Assisted Bayesian Designs for Dose Finding and Optimization (Chapman & Hall/CRC Biostatistics Series) 1st Edition
By  Ying Yuan (Author), Ruitao Lin (Author), J. Jack Lee (Author) 

Key Features:

  • Comprehensive Coverage: The first book to provide in-depth exploration of model-assisted designs for dose-finding and optimization trials.
  • Up-to-date Theory & Practice: Detailed discussion of the latest approaches in model-assisted designs.
  • Practical Challenges & Solutions: Highlights real-world issues faced in early-phase clinical trials and offers actionable solutions.
  • Real Trial Applications: Includes case studies and practical examples to illustrate the application of these designs.
  • Guidance on Trial Design: Offers step-by-step advice on how to design and optimize dose-finding trials.
  • Companion Website: Provides easy-to-use, freely available software (www.trialdesign.org) for learning and implementing model-assisted designs.
  • Expert Authorship: Written by leaders from the University of Texas MD Anderson Cancer Center, pioneers in model-assisted designs.
Model-Assisted Bayesian Designs for Dose Finding and Optimization (Chapman & Hall/CRC Biostatistics Series) 1st Edition Now Available at Ganagaram Jinnah Medical Bookshop For home delivery and Cash on delivery to all over Pakistan.
Buy online Medical books  at Gangaram Jinnah Medical Books Shop for home delivery and Cash on delivery to all over Pakistan. All kind of medical books are available.

Additional information

Quality

Black & white, Colour Matt Finish

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